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Shixin ZHANG,Shaohua WU,Weimin TIAN
《农业科学与工程前沿（英文）》 2016年 第3卷 第4期 页码 357-362 doi: 10.15302/J-FASE-2016125
关键词： Hevea brasiliensis histone acetylation laticifer differentiation trichostatin vascular cambia
Emerging roles of podoplanin in vascular development and homeostasis
null
《医学前沿（英文）》 2015年 第9卷 第4期 页码 421-430 doi: 10.1007/s11684-015-0424-9
Podoplanin (PDPN) is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells (LECs) in the vascular system and fibroblastic reticular cells (FRCs) in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Prox1 and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.
关键词： podoplanin CLEC-2 Prox1 O-glycosylation lymphatic vascular development and maintenance lymphoid organ homeostasis
Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty
Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU
《医学前沿（英文）》 2009年 第3卷 第2期 页码 177-180 doi: 10.1007/s11684-009-0021-x
关键词： vascular endothelial growth factors restenosis reactive oxygen species endothelial cells vascular smooth muscle cell
Crk-associated substrate, vascular smooth muscle and hypertension
TANG Dale
《医学前沿（英文）》 2008年 第2卷 第4期 页码 323-331 doi: 10.1007/s11684-008-0062-6
关键词： Contraction stimulation phosphatase-proline molecular structure discovered hypertension
Role of nitric oxide in biological effects of vascular endothelial growth factor
Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,
《医学前沿（英文）》 2009年 第3卷 第3期 页码 284-286 doi: 10.1007/s11684-009-0062-1
关键词： vascular endothelial growth factor nitric oxide N-nitro-L-arginine methyl ester vascular endothelial cells
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
《医学前沿（英文）》 2012年 第6卷 第1期 页码 67-78 doi: 10.1007/s11684-012-0176-8
Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy, resulting in tumor recurrence in patients after several months of treatment. Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues, which fosters tumor cells to become more aggressive and metastatic. In 2001, Jain proposed tumor vascular normalization as an alternative approach to treating cancers based on the pioneering work on tumor blood vessels by several other researchers. At present, normalizing the disorganized tumor vasculature, rather than disrupting or blocking them, has emerged as a new option for anticancer therapy. Preclinical and clinical data have shown that tumor vascular normalization using monoclonal antibodies, proteins, peptides, small molecules, and pericytes resulted in decreased tumor size and reduced metastasis. However, current tumor vascular normalizing drugs display moderate anticancer efficacy. Accumulated data have shown that a variety of vasculogenic/angiogenic tumor cells and genes play important roles in tumor neovascularization, growth, and metastasis. Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor vascular normalization. To this end, the combination of antiangiogenic drugs with tumor vascular normalizing therapeutics, as well as the integration of Western medicine with traditional Chinese medicine, may provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer therapy.
关键词： angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine
null
《医学前沿（英文）》 2016年 第10卷 第3期 页码 320-329 doi: 10.1007/s11684-016-0463-x
Coronary atherosclerosis is a major complication of chronic kidney disease. This condition contributes to the increased mortality in dialysis patients. p-Cresyl sulfate (PCS) is a prototype of protein-bound uremic toxins that cannot be efficiently removed through routine dialysis procedures. In the present study, ApoE−/− mice that underwent 5/6 nephrectomy were randomly divided into two groups, namely, vehicle-treated group (n = 20) and PCS-treated group (n = 20). Mice were sacrificed for en face and immunohistological analyses after 8 or 24 weeks of high-fat diet. Rat aortic vascular smooth muscle cells (VSMCs) were treated with phosphate buffer solution or 500 µmol/L PCS for in vitro evaluation. PCS-treated mice were observed to suffer increased atherosclerotic lesions after eight weeks of PCS administration. Moreover, 24 weeks of PCS administration also markedly increased the vulnerability index of aortic plaques. PCS was also observed to facilitate the migration and proliferation of VSMCs during the progression of the disease. Moreover, PCS disturbed the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases within the plaques. Thus, PCS played a vital role in promoting atherogenesis and disturbing the stability of formed plaques probably by targeting VSMCs.
关键词： p-cresyl sulfate atherosclerosis plaque stability vascular smooth muscle cell
null
《医学前沿（英文）》 2017年 第11卷 第3期 页码 403-409 doi: 10.1007/s11684-017-0522-y
Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.
关键词： arterial thrombosis conditional knockout mice tissue factor pathway inhibitor vascular smooth muscle cells
Fanfan Li, Mengzhou He, Meitao Yang, Yao Fan, Yun Chen, Xi Xia, Yin Xie, Dongrui Deng
《医学前沿（英文）》 2018年 第12卷 第5期 页码 542-549 doi: 10.1007/s11684-017-0576-x
Preeclampsia (PE) is a pregnancy-specific, multi-system disorder and the leading cause of maternal and perinatal morbidity and mortality in obstetrics worldwide. Excessive vasoconstriction and dysregulated coagulation function are closely associated with PE. Heat shock protein 20 (HSP20) is ubiquitously expressed under normal physiological conditions and has important roles in vascular dilatation and suppression of platelet aggregation. However, the role of HSP20 in the pathogenesis of PE remains unclear. In this study, we collected chorionic plate resistance arteries (CPAs) and serum from 118 healthy pregnant women and 80 women with PE and detected the levels of HSP20 and its phosphorylated form. Both HSP20 and phosphorylated HSP20 were downregulated in CPAs from women with PE. Comparison of the vasodilative ability of CPAs from the two groups showed impaired relaxation responses to acetyl choline in preeclamptic vessels. In addition to the reduced HSP20 in serum from women with PE, the platelet distribution width and mean platelet volume were also decreased, and the activated partial thromboplastin time and thromboplastin time were elevated. With regard to the vital roles of HSP20 in mediating vasorelaxation and coagulation function, the decreased HSP20 might contribute to the pathogenesis of PE.
关键词： preeclampsia heat shock protein 20 vascular relaxation coagulation-fibrinolytic system
Visualization of vascular ultrastructure during osteogenesis by tissue engineering technique
ZHANG Kaigang, ZENG Bingfang, ZHANG Changqing
《医学前沿（英文）》 2007年 第1卷 第2期 页码 181-184 doi: 10.1007/s11684-007-0034-2
关键词： feasibility engineering osteogenesis vascularization microscopy
Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,
《医学前沿（英文）》 2010年 第4卷 第2期 页码 225-228 doi: 10.1007/s11684-010-0003-z
关键词： bradykinin vascular smooth muscle cells signal transduction pathways
null
《医学前沿（英文）》 2012年 第6卷 第3期 页码 329-331 doi: 10.1007/s11684-012-0211-9
Ischemic postconditioning was defined as rapid intermittent interruptions of blood ?ow in the early phase of reperfusion, which has been found to be protective against renal ischemia-reperfusion injury (IRI) in animal models but not in clinical trials. We describe a case that the allograft renal vein was twisted because of the surgeon’s mistake, which caused the warm ischemia of allograft after reperfusion. The allograft restored blood flow without second reperfusion and cold preservation after 9 min of warm ischemia. The patient was followed up for 3 months and the allograft worked well without complications.
关键词： renal transplantation vein twist ischemia-reperfusion injury
null
《医学前沿（英文）》 2012年 第6卷 第1期 页码 22-34 doi: 10.1007/s11684-012-0178-6
Stroke is a personal, familial, and social disaster. It is the third cause of death worldwide, the first cause of acquired disability, the second cause of dementia, and its cost is astronomic. The burden of stroke is likely to increase given the aging of the population and the growing incidence of many vascular risk factors. Prevention of stroke includes—as for all other diseases—a “mass approach” aiming at decreasing the risk at the society level and an individual approach, aiming at reducing the risk in a given subject. The mass approach is primarily based on the identification and treatment of vascular risk factors and, if possible, in the implementation of protective factors. These measures are the basis of primary prevention but most of them have now been shown to be also effective in secondary prevention. The individual approach combines a vascular risk factor modification and various treatments addressing the specific subtypes of stroke, such as antiplatelet drugs for the prevention of cerebral infarction in large and small artery diseases of the brain, carotid endarterectomy or stenting for tight carotid artery stenosis, and oral anticoagulants for the prevention of cardiac emboli. There is a growing awareness of the huge evidence-to-practice gap that exists in stroke prevention largely due to socio-economic factors. Recent approaches include low cost intervention packages to reduce blood pressure and cheap “polypills” combining in a single tablet aspirin and several drugs to lower blood pressure and cholesterol. Polypill intake should however not lead to abandon the healthy life-style measures which remain the mainstay of stroke prevention.
关键词： stroke prevention vascular risk factors cerebral infarction cerebral hemorrhage anti-thrombotic drugs carotid endarterectomy
LI Tao, YANG Guangming, XU Jing, LIU Jiancang, LIU Liangming
《医学前沿（英文）》 2008年 第2卷 第3期 页码 248-254 doi: 10.1007/s11684-008-0047-5
Vein of Galen malformations - report of 2 cases and literature review
CAI Chunquan, ZHANG Qingjiang, SHEN Changhong
《医学前沿（英文）》 2008年 第2卷 第3期 页码 317-322 doi: 10.1007/s11684-008-0061-7
关键词： underwent embolization angiography pediatric vascular cognitive characteristic
标题 作者 时间 类型 操作
The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of histone acetylation
Shixin ZHANG,Shaohua WU,Weimin TIAN
期刊论文
Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty
Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU
期刊论文
Role of nitric oxide in biological effects of vascular endothelial growth factor
Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,
期刊论文
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
期刊论文
sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by targeting vascular
null
期刊论文
Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis
null
期刊论文
Alteration of heat shock protein 20 expression in preeclamptic patients and its effect in vascular and
Fanfan Li, Mengzhou He, Meitao Yang, Yao Fan, Yun Chen, Xi Xia, Yin Xie, Dongrui Deng
期刊论文
Visualization of vascular ultrastructure during osteogenesis by tissue engineering technique
ZHANG Kaigang, ZENG Bingfang, ZHANG Changqing
期刊论文
Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved
Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,
期刊论文
The second short-term warm ischemia after vascular anastomosis did not affect early renal function recovery
null
期刊论文
Beneficial effect of arginine vasopressin on hemorrhagic shock through improving the vascular reactivity
LI Tao, YANG Guangming, XU Jing, LIU Jiancang, LIU Liangming
期刊论文
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